Missouri Southern State University is accredited by Higher Learning Commission. It has 5 programmatic accredited programs.
The following table describes the detail information of institutional accreditation information.
Institutional Accreditation
| Agency Name | Accreditation Status | Periods |
| Higher Learning Commission | Accredited | 1/1/1949 - Current (Estimated Date) |
Programmatic Accreditation
| Program | Accreditation Status | Periods |
| Nursing (NUR) - Baccalaureate program | Accredited | 3/1/1990 - Current (Estimated Date) |
| Program | Accreditation Status | Periods |
| Dental Hygiene (DH) | Accredited | 5/8/1975 - Current |
| Program | Accreditation Status | Periods |
| Nursing (CNURED) - Nursing education programs at the graduate degree levels | Accredited | 11/9/2009 - 12/20/2014 |
| Program | Accreditation Status | Periods |
| Radiologic Technology (RAD) - Programs for radiographers | Accredited | 4/1/1972 - Current (Estimated Date) |
| Program | Accreditation Status | Periods |
| Baccalaureate Degree Nursing Programs | Accredited | 7/1/1981 - Current |